کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1428032 | 1509158 | 2016 | 18 صفحه PDF | دانلود رایگان |
• Synthesis of novel mesoporous silica-based curcumin drug delivery system
• Slow and sustained release of curcumin in blood simulated fluid
• Enhanced cytotoxicity of curcumin in three diverse cancer cell lines
• Cancer cell migration inhibition and generation of superoxide radicals
• Activation of apoptosis by DNA damage and down regulation of BCL-2, EGFR proteins
Two different silica based (MSU-2 and MCM-41) curcumin loaded mesoporous materials V3 and V6 were synthesized and characterized by several physico-chemical techniques. Release kinetic study revealed the slow and sustained release of curcumin from those materials in blood simulated fluid (pH: 7.4). The materials V3 and V6 were found to be biocompatible in non-cancerous CHO cell line while exhibiting significant cytotoxicity in different cancer cells (human lung carcinoma cells: A549, human breast cancer cells: MCF-7, mouse melanoma cells: B16F10) compared to pristine curcumin indicating the efficacy of the mesoporous silica materials based drug delivery systems (DDSs). The generation of intracellular reactive oxygen species (ROS) and down regulation of anti-apoptotic protein leading to the induction of apoptosis were found to be the plausible mechanisms behind the anti-cancer activity of these DDSs. These results suggest that curcumin-loaded drug delivery system may be successfully employed as an alternative treatment strategy for cancer therapeutics through a nanomedicine approach in near future.
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Journal: Materials Science and Engineering: C - Volume 63, 1 June 2016, Pages 393–410