Determination of buprenorphine by differential pulse voltammetry on carbon paste electrode using SDS as an enhancement factor

• Buprenorphine (BPR) was detected with differential pulse voltammetry at CPE in the presence of SDS.
• The method was a simple, rapid, accurate, and low cost technique of BPR determination.
• The nanomolar detection limit was obtained.
• The method was applied for the measurement of BPR in urine samples.
• A wide linear range with low detection limit obtained at CPE in the presence of SDS compared to the other reports

In the present study, a facile electrochemical approach is proposed for the determination of buprenorphine (BPR) in the presence of sodium dodecyl sulfate (SDS). SDS was applied for amplification of oxidation signal. Carbon paste electrode (CPE) used as working electrode and cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) were carried out in phosphate buffer solution (pH 3.0). Under optimal experimental conditions, the oxidation current increased with the addition of BPR in the sample and two dynamic ranges obtained from 4.00 nM to 0.126 μM and from 0.126 to 0.317 μM by DPV and exhibited a low detection limit (LOD) of 1.33 nM (S/N = 3). This offered method has been used for the determination of BPR in the real samples and has validated with the recovery test for BPR spiked urine samples. The result demonstrated that this method is a simple, sensitive, rapid, low-cost, and stable method for BPR detection.

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