کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1642133 1517221 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emulsion electrospun composite matrices of poly(ε-caprolactone)-hydroxyapatite: Strategy for hydroxyapatite confinement and retention on fiber surface
ترجمه فارسی عنوان
ماتریس های کامپوزیت الکترو اسپون امولسیون پلی (یو کاپرولاکتون) هیدروکسی آپاتیت: استراتژی برای محصور کردن هیدروکسی آپاتیت و حفظ سطح فیبر
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی

Fabrication of polymeric scaffolds for various applications usually involve organic solvents or high temperature, causing the process to be unsuitable for sensitive polymers or ingredients. Here we present a method to make stable oil-in-water emulsions of poly(ɛ-caprolactone) (PCL) with hydroxyapatite (HA) and produce porous composite matrices from resultant emulsions via electrospinning. The emulsions are made using minimal quantity of an organic solvent and the matrices are produced via emulsion electrospinning thereby retaining the HA activity and yield in the final product. HA is confined within the PCL solution which is then dispersed in aqueous phase containing poly(vinyl alcohol) (PVA) used as a template polymer. Subsequent treatment of matrices is done to enhance HA's presence on fiber surface of the matrix and the effect of HA loading on emulsion properties, fiber morphology and proliferation profile of osteoblasts on resultant matrices is studied. Enhanced osteoblast attachment and proliferation is observed on the matrices developed via emulsion electrospinning due to uneven surface of the fibers and presence of HA on the surface. The method adopted to develop PCL/HA based porous matrices via emulsion electrospinning is substantiated to be an advantageous way to generate scaffolds favorable for applications including biomedical besides others.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 167, 15 March 2016, Pages 288–296
نویسندگان
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