|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|2093883||1401346||2016||4 صفحه PDF||سفارش دهید||دانلود کنید|
Skin fibroblasts were obtained from a male patient diagnosed with retinoblastoma (RB) carrying a c.2663G > A mutation in the 25 exon of RB1 gene. RB-iPS cells was generated via delivered four reprogramming factors (OCT4, SOX2, NANOG and LIN28) into these skin fibroblasts. The RB-iPS cells retained the RB1 heterozygous mutation resulted in a truncated RB1 mRNA. Characteristic tests proved that the iPSC line presented typical markers of pluripotency and had the capability to form the three germ layers in vitro.
Journal: Stem Cell Research - Volume 17, Issue 2, September 2016, Pages 208–211