کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2112571 | 1084400 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Highlight
• TGF-β circulating levels are not related to more advanced stage of HCC.
• The inverse correlation TGF-β/E-cadherin supports the role of TGF-β in EMT.
• E-cadherin, MMP-2 and VEGF are related to TGF-β activity.
• These biomarkers could help to select candidates for receiving a TGF-β inhibitor.
TGF-β1 was inversely correlated with E-cadherin but significantly correlated with VEGF. VEGF and AFP had a low coefficient value but statistically significant. A significant correlation was found between E-cadherin and MMP2. In conclusion, TGF-β and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 353, Issue 2, 28 October 2014, Pages 264–271
Journal: Cancer Letters - Volume 353, Issue 2, 28 October 2014, Pages 264–271
نویسندگان
Francesco Dituri, Gabriella Serio, Doriana Filannino, Antonella Mascolo, Rodolfo Sacco, Erica Villa, Gianluigi Giannelli,