کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167065 1092304 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunomodulation of macrophages by methylglyoxal conjugated with chitosan nanoparticles against Sarcoma-180 tumor in mice
ترجمه فارسی عنوان
ایمونوادولوژی ماکروفاژها توسط متیل گلیکسال کنگویی شده با نانوذرات کیتوزان در برابر تومور سروکوام 180 در موش سوری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• We developed a methylglyoxal chitosan conjugate called ‘Nano-MG’.
• This compound has anticancer and immunomodulatory role.
• Nano-MG reduced murine Sarcoma-180 tumor volume.
• Nano-MG upregulated macrophage cytokines in tumor bearing mice.

Methylglyoxal (MG), the potent anticancer agent has been conjugated to a nontoxic, biocompatible polymer, chitosan, to protect it from in vivo enzymatic degradation. This polymeric complex, ‘Nano-MG’ shows remarkable antitumor property and elicits macrophage-mediated immunity in tumor bearing mice on intravenous (0.4 mg/kg body wt/day) treatment more efficiently than MG (20 mg/kg body wt/day). These activated macrophages appear more in numbers in the peritoneum and produce more superoxide and nitrite. Moreover, immunomodulatory cytokines and surface receptors of these macrophages like iNOS, IFN-γ, TNF-α, IL-1β, IL-6, M-CSF, TLR-4 and TLR-9 also exhibit marked up-regulation in Sarcoma-180 tumor bearing mice after Nano-MG treatment compared to untreated tumor bearing counterpart. Hence, Nano-MG acts as an immunostimulant in tumor bearing mice to combat cancer at conspicuously lower dose, probably due to its longer circulation time in blood.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 287, Issue 1, January 2014, Pages 27–35
نویسندگان
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