کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167157 1549405 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crohn’s disease: A review of treatment options and current research
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Crohn’s disease: A review of treatment options and current research
چکیده انگلیسی


• The etiology of Crohn’s disease is still not completely understood.
• We examine the immune system’s role in Crohn’s disease.
• We examine commonly used biologics to treat Crohn’s disease at the molecular level.
• We examine drugs under current investigation as potential treatment options at the molecular level.

Crohn’s disease is an autoimmune disorder that affects nearly 1.4 million Americans. The etiology of Crohn’s disease is not completely understood, however, research has suggested a genetic link. There is currently no known cure for Crohn’s disease and, as a result, most government-funded research is being conducted to increase the quality of life of afflicted patients (i.e. reducing chronic inflammation and alleviating growth impairment in pediatric patients). A number of treatment options are available including an alpha-4 integrin inhibitor and several TNF-alpha inhibitors. Furthermore, research is being conducted on several alternative treatment options to help understand exactly which cellular mechanisms (i.e. inducing apoptosis in leukocytes) are required for clinical efficacy. This review seeks to chronicle the current available treatment options for patients affected by Crohn’s disease to aid in understanding potential cellular mechanistic requirements for an efficacious drug, and shed light on potential options for future treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 286, Issues 1–2, November–December 2013, Pages 45–52
نویسندگان
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