کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2195593 | 1550853 | 2016 | 7 صفحه PDF | دانلود رایگان |
• Comprehensive analysis of cytokine gene polymorphisms in children with AITD.
• Twenty five SNPs of 17 cytokine genes could be simultaneously typed in single tube.
• IL-12 (rs3212227: A>C) allele was associated with ophthalmopathy in children AITD.
• IL-12 impacts on pathogenesis of ophthalmopathy in children with AITD.
In early onset autoimmune thyroid disease (AITD) showing a strong genetic tendency, cytokines have been suggested to play a critical role in the development of AITD. To directly compare the influences of several cytokine gene polymorphisms, 25 single nucleotide polymorphisms (SNPs) in 17 cytokine genes were analyzed on 104 Korean children with AITD [Hashimoto's disease (HD) = 44, Graves' disease (GD) = 60 (thyroid-associated ophthalmopathy (TAO) = 29, non-TAO = 31)] and 192 controls. Compared with healthy controls, any significant association with polymorphisms of cytokine genes was not found in HD and GD. Among GD patients, non-TAO group only showed significant associations with IL-12 C allele (rs3212227: A > C) (76.6% vs. 51.6%, OR = 0.3 [0.15–0.71], Pc = 0.007). Particularly, the frequency of IL-12C allele was significantly lower in the non-TAO group than in the TAO group (82.8% vs. 51.6%, Pc = 0.018). Our comprehensive analysis of cytokine gene polymorphisms suggests that IL-12 gene may play impact on specific pathogenesis of ophthalmopathy in Korean children with AITD.
Journal: Molecular and Cellular Endocrinology - Volume 426, 5 May 2016, Pages 43–49