کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501845 1557364 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anionic polymers and 10 nm Fe3O4@UA wound dressings support human foetal stem cells normal development and exhibit great antimicrobial properties
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Anionic polymers and 10 nm Fe3O4@UA wound dressings support human foetal stem cells normal development and exhibit great antimicrobial properties
چکیده انگلیسی

The aims of this study were the development, characterization and bioevaluation of a novel biocompatible, resorbable and bio-active wound dressing prototype, based on anionic polymers (sodium alginate – AlgNa, carboximethylcellulose – CMC) and magnetic nanoparticles loaded with usnic acid (Fe3O4@UA). The antimicrobial activity was tested against Staphylococcus aureus grown in biofilms. The biocompatibility testing model included an endothelial cell line from human umbilical vein and human foetal progenitor cells derived from the amniotic fluid, that express a wide spectrum of surface molecules involved in different vascular functions and inflammatory response, and may be used as skin regenerative support. The obtained results demonstrated that CMC/Fe3O4@UA and AlgNa/Fe3O4@UA are exhibiting structural and functional properties that recommend them for further applications in the biomedical field. They could be used alone or coated with different bio-active compounds, such as Fe3O4@UA, for the development of novel, multifunctional porous materials used in tissues regeneration, as antimicrobial substances releasing devices, providing also a mechanical support for the eukaryotic cells adhesion, and exhibiting the advantage of low cytotoxicity on human progenitor cells. The great antimicrobial properties exhibited by the newly synthesized nano-bioactive coatings are recommending them as successful candidates for improving the implanted devices surfaces used in regenerative medicine.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 463, Issue 2, 25 March 2014, Pages 146–154
نویسندگان
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