کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3282723 | 1209158 | 2013 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diagnosis and Treatment of Gastrointestinal Disorders in Patients With Primary Immunodeficiency
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کلمات کلیدی
CGDMercaptopurineIPEXAZAXLACVIDGvHDSCIDTNFIBDWASPFOXP3NLH6-MP - 6 مگاپیکسلazathioprine - آزاتیوپرین STAT - آمارX-linked agammaglobulinemia - اگاماگلوبولینمی مرتبط با Ximmunoglobulin - ایمونوگلوبولینinterleukin - اینترلوکینWAS - بودGraft-versus-host disease - بیماری مرض در برابر میزبانchronic granulomatous disease - بیماری گرانولوماتوز مزمنforkhead box P3 - جعبه جعبه P3Immune system - دستگاه ایمنی یا سیستم ایمنیGastrointestinal - دستگاه گوارشWiskott–Aldrich syndrome - سندرم Wiskott-Aldrichtumor necrosis factor - فاکتور نکروز تومورSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیSCID, Severe combined immunodeficiency - نقص ایمنی مرکب شدیدNodular lymphoid hyperplasia - هیپرپلازی لنفاوی مفصلیHypogammaglobulinemia - هیپوگاماگلوبولینمیWiskott–Aldrich syndrome protein - پروتئین سندرم Wiskott-AldrichCommon variable immunodeficiency - کمبود ایمنی متغیر مشترک
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Gastrointestinal disorders such as chronic or acute diarrhea, malabsorption, abdominal pain, and inflammatory bowel diseases can indicate immune deficiency. The gastrointestinal tract is the largest lymphoid organ in the body, so it is not surprising that intestinal diseases are common among immunodeficient patients. Gastroenterologists therefore must be able to diagnose and treat patients with primary immunodeficiency. Immune-related gastrointestinal diseases can be classified as those that develop primarily via autoimmunity, infection, an inflammatory response, or malignancy. Immunodeficient and immunocompetent patients with gastrointestinal diseases present with similar symptoms. However, intestinal biopsy specimens from immunodeficient patients often have distinct histologic features, and these patients often fail to respond to conventional therapies. Therefore, early recognition of symptoms and referral to an immunologist for a basic immune evaluation is required to select appropriate treatments. Therapies for primary immunodeficiency comprise immunoglobulin replacement, antibiotics, and, in severe cases, bone marrow transplantation. Treatment of immunodeficient patients with concomitant gastrointestinal disease can be challenging, and therapy with immunomodulators often is required for severe disease. This review aims to guide gastroenterologists in the diagnosis and treatment of patients with primary immunodeficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 11, Issue 9, September 2013, Pages 1050-1063
Journal: Clinical Gastroenterology and Hepatology - Volume 11, Issue 9, September 2013, Pages 1050-1063
نویسندگان
Shradha Agarwal, Lloyd Mayer,