کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285768 | 1209240 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum Apoptosis Markers in Acute Liver Failure: A Pilot Study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
INRTNFALFSGsFasHGFALFIL-6Drug-induced liver injury - آسیب کبدی ناشی از مواد مخدرinterferon - اینترفرونIFN - اینترفرون هاinterleukin-6 - اینترلوکین ۶ELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاDILI - دیلیHepatocyte growth factor - عامل رشد هپاتوسیتtumor necrosis factor - فاکتور نکروز تومورsoluble Fas - محلول FasAcute liver failure - نارسایی حاد کبدیInternational Normalized Ratio - نسبت عادی بین المللی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: We sought to determine whether circulating apoptotic markers are altered in acute liver failure (ALF), differ with etiology, or predict clinical outcome in this condition. Methods: Serum levels of soluble Fas (sFas), tumor necrosis factor-alpha (TNF-α), hepatocyte growth factor (HGF), and interleukin-6 (IL-6) were measured in 67 acute liver failure patients, as well as controls. In a subset of the groups, we measured serum M-30 antigen, an exposed neoepitope from caspase cleavage. We also assessed M-30 immunoreactivity in liver tissue of ALF patients and controls. Results: Median levels for TNF-α, HGF, IL-6, and M-30 antigen were at least 10-fold greater in ALF than in hepatitis C virus or normal controls (P < .0001). Median day 1 sFas, day 3 sFas, and day 1 HGF levels varied according to etiology of acute liver failure (P = .004, P = .011, and P = .019, respectively), with values for drug-induced liver injury and acetaminophen-related ALF higher than other etiologies. Median M-30 antigen levels were significantly higher in patients who were transplanted and/or died (2183 U/L) than spontaneous survivors (1004 U/L) (P = .026). M-30 immunoreactivity in liver tissue was significantly greater in ALF patients than HCV controls (P = .004). Conclusions: TNF-α, HGF, IL-6, and M-30 antigen were significantly elevated in ALF. High levels of sFas and HGF might help to confirm a diagnosis of drug-induced liver injury or acetaminophen-related ALF. Higher levels of M-30 antigen are associated with poor clinical outcomes in ALF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 12, December 2007, Pages 1477-1483
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 12, December 2007, Pages 1477-1483
نویسندگان
Anna E. Rutherford, Linda S. Hynan, Carolina B.S. Borges, David G. Forcione, Jason T. Blackard, Wenyu Lin, April R. Gorman, Obaid Shakil Shaikh, Adrian Reuben, Edwyn Harrison, K. Rajender Reddy, William M. Le, Raymond T. Chung,