کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3420794 | 1594018 | 2008 | 8 صفحه PDF | دانلود رایگان |
SummaryIn order to document the effect of treatment delay on tuberculosis (TB) latent infection among the household contacts of TB patients, a cross-sectional TB infection prevalence survey was conducted among household contacts in Yunnan Province, southern China. In total, 1360 household contacts of 393 smear-positive pulmonary TB patients were enrolled, together with 308 household contacts of 90 non-TB patients. Using the contacts of non-TB patients as the baseline of TB infection, there was a dose–response relationship between household infection and delay of TB treatment (TB infection prevalence 9.7, 7.8, 19.9, 25.7 and 26.9% for non-TB case, TB case with delay ≤30 d, 30–60 d, 60–90 d and >90 d, respectively). Older age, TB index patient with lung cavitation, and sleeping in the same bedroom with a TB patient were all associated with an increased risk of being tuberculin-skin-test positive. In conclusion, 30 d delay in treatment seems to be the turning point at which a significant increase in risk for TB infection occurs. Apart from conventional indicators, magnitude of treatment delay should be considered as a performance indicator for TB control programmes in high-TB-burden countries. Measures for the detection of early cases should be intensified.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 102, Issue 8, August 2008, Pages 797–804