Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti-Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography

Eyes with vascularized PEDs secondary to AMD may show specific OCT findings that increase the risk for RPE tear following intravitreal anti-VEGF injection. Rapid involution and contraction of neovascular tissue adherent to the undersurface of the RPE may impart a substantial contractile force that tears this already-strained tissue layer.