کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
417497 | 681529 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exact statistical power for response adaptive designs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نظریه محاسباتی و ریاضیات
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This paper develops a unified method to compute the exact statistical power for a general class of response adaptive designs including the randomized play-the-winner design, the drop-the-loser design, and the doubly biased coin design. The adaptation of treatment allocation in response adaptive designs is formulated as a Markov chain. The exact statistical power is computed based on the transition probability of the formulated Markov chain. The proposed approach is demonstrated through the ECMO trial example. The difference between the asymptotic and exact statistical power is also explored for large sample sizes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Statistics & Data Analysis - Volume 58, February 2013, Pages 201–209
Journal: Computational Statistics & Data Analysis - Volume 58, February 2013, Pages 201–209
نویسندگان
Yanqing Yi,