کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5033016 1370004 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
چکیده انگلیسی
Nanoparticles were developed to effectively deliver siRNA into brain cancer cells. Knockdown of the multifunctional DNA repair enzyme apurinic endonuclease 1 (Ape1) through nanoparticle-mediated delivery of anti-Ape1 siRNA sensitizes brain tumor cells to radiotherapy and significantly extends survival as demonstrated in a genetic mouse model of glioblastoma.164
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 13, Issue 7, October 2017, Pages 2131-2139
نویسندگان
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