کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5040668 1473904 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal immune activation transgenerationally modulates maternal care and offspring depression-like behavior
ترجمه فارسی عنوان
فعال سازی ایمنی مادر از طریق تربیت نسبی مراقبت های مادرانه و رفتار افسردگی فرزندان را مدون می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Maternal immune activation (MIA) during pregnancy impacts maternal care behavior.
- Modulation of maternal care behavior in female offspring after gestational immune challenge depends on history of MIA of male mating partner.
- Second generation offspring after grand-parental gestational immune challenge display augmented depression-like behavior.
- Transcriptional changes in the hippocampus of first and second generation offspring with history of MIA are both, conserved and modified, across generations.

Gestational infection is increasingly being recognized for its involvement as causative mechanism in severe developmental brain abnormalities and its contribution to the pathogenesis of psychopathologies later in life. First observations in the widely accepted maternal immune activation (MIA) model based upon the systemic administration of the viral mimetic Polyinosinic:polycytidylic acid (poly(I:C)) have recently suggested a transmission of behavioral and transcriptional traits across generations. Although maternal care behavior (MCB) is known as essential mediator of the transgenerational effects of environmental challenges on offspring brain function and behavior, the possible propagation of alterations of MCB resulting from MIA to following generations has not yet been examined. Here we show that poly(I:C) stimulation at embryonic day 12.5 (E12.5) leads to aberrant MCB and that this effect is transmitted to the female F1 offspring. The transgenerational effects on MCB are paralleled by enhanced depression-like behavior in the second generation F2 offspring with contributions of both maternal and paternal heritages. Examination of offspring hippocampal expression of genes known as targets of MCB and relevant for ensuing non-genetic transmission of altered brain function and behavior revealed transgenerationally conserved and modified expressional patterns in the F1 and F2 generation.Collectively these data firstly demonstrate the transgenerational transmission of the impact of gestational immune activation on the reproductive care behavior of the mother. Behavioral and molecular characteristics of first and second generation offspring suggest transgenerationally imprinted consequences of gestational infection on psychopathological traits related to mood disorders which remain to be examined in future cross-fostering experiments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 63, July 2017, Pages 127-136
نویسندگان
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