کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5043535 1475297 2017 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A systematic review of the psychobiological burden of informal caregiving for patients with dementia: Focus on cognitive and biological markers of chronic stress
ترجمه فارسی عنوان
بررسی سیستماتیک بار روانی شناختی مراقبت غیر رسمی مراقبت از بیماران مبتلا به زوال عقل: تمرکز بر نشانگرهای شناختی و بیولوژیکی تنش مزمن
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Much research has examined biomarkers of chronic stress in dementia caregivers.
- Cortisol was increased in dementia caregivers in most studies examining cortisol.
- Dementia caregivers displayed poorer attention and executive function performance.
- Interventions to reduce stress in caregivers may improve cognition.
- Risk of bias was generally low to moderate.

As the physiological impact of chronic stress is difficult to study in humans, naturalistic stressors are invaluable sources of information in this area. This review systematically evaluates the research literature examining biomarkers of chronic stress, including neurocognition, in informal dementia caregivers.We identified 151 papers for inclusion in the final review, including papers examining differences between caregivers and controls as well as interventions aimed at counteracting the biological burden of chronic caregiving stress.Results indicate that cortisol was increased in caregivers in a majority of studies examining this biomarker. There was mixed evidence for differences in epinephrine, norepinephrine and other cardiovascular markers. There was a high level of heterogeneity in immune system measures. Caregivers performed more poorly on attention and executive functioning tests. There was mixed evidence for memory performance. Interventions to reduce stress improved cognition but had mixed effects on cortisol. Risk of bias was generally low to moderate. Given the rising need for family caregivers worldwide, the implications of these findings can no longer be neglected.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 73, February 2017, Pages 123-164
نویسندگان
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