کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5135545 1493429 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rods-on-sphere silica particles for high performance liquid chromatography
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Rods-on-sphere silica particles for high performance liquid chromatography
چکیده انگلیسی


- Core-shell silica particles were prepared by one-pot sol-gel method.
- The shell was composed with rods that perpendicular to the particle surface.
- Particles packed column exhibits high efficiency, good stability and reproducibility.

Silica spheres covered with rods perpendicular to the particle surface were prepared by a simple one-pot sol-gel process. Thus prepared rods-on-sphere silica particles possessed core-shell structure. Compared to other core-shell silica particles in which the shell was synthesized by the time-consuming multiple-step layer-by-layer coating technique, the shell of our rods-on-sphere particles was formed by directly grown rods from the silica spheres. The coverage of the rods on the particle surface could be tuned by changing the amount of water in the reaction. The rods on the particle surface increased the surface roughness which may help decreasing the A-term. Therefore, the calcined and modified rods-on-sphere silica particles were packed into stainless steel columns and then assessed for the separation of various samples including small molecules and proteins. In comparison with a commercially available Kromasil column, the pressure of the rods-on-sphere column is much lower under the same separation conditions, while the column efficiency was comparable. The separation results demonstrate that rods-on-sphere silica particles are a type of new and highly promising packing stationary phase for high performance liquid chromatography.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1497, 12 May 2017, Pages 87-91
نویسندگان
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