کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5137083 1378962 2017 9 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Effect of phenolic hydroxyl groups on inhibitory activities of phenylpropanoid glycosides against lipase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Effect of phenolic hydroxyl groups on inhibitory activities of phenylpropanoid glycosides against lipase
چکیده انگلیسی


- The inhibition and binding affinities of PPGs for lipase were analyzed.
- The hydrogen bond plays an important role in the interaction between PPGs and lipase.
- With increasing phenolic hydroxyl groups on PPGs, the interaction increase.
- The inhibitory effect of phenolic hydroxyl group is higher at the A-ring than B-ring.

The phenolic hydroxyl group in polyphenols is a significant structural feature to for understanding their inhibition of lipase. In this paper, we studied four phenylpropanoid glycosides (PPGs) (acteoside, lipedoside A-I, syringalide A 3′-α-l-rhamnopyranoside and osmanthuside B) with different numbers and positions of the phenolic hydroxyl groups in terms of their inhibition of and affinities for porcine pancreatic lipase. The inhibitory effects on lipase were in the order of acteoside (IC50 = 2.17 ± 0.13 mg/ml) > syringalide A 3′-α-l-rhamnopyranoside (IC50 = 3.87 ± 0.21 mg/ml) > lipedoside A-I (IC50 = 4.27 ± 0.22 mg/ml) > osmanthuside B (IC50 = 23.14 ± 0.51 mg/ml). The order of binding affinity to lipase was acteoside > syringalide A 3′-α-l-rhamnopyranoside > lipedoside A-I > osmanthuside B. The hydrogen bond plays an important role in the interaction between PPGs and lipase. With increasing phenolic hydroxyl groups in PPGs, their binding affinities and inhibition for lipase increased.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 38, Part A, November 2017, Pages 510-518
نویسندگان
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