کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5137166 1494534 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of luteolin on inflammatory responses in RAW264.7 macrophages activated with LPS and IFN-γ
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Effect of luteolin on inflammatory responses in RAW264.7 macrophages activated with LPS and IFN-γ
چکیده انگلیسی
Luteolin (Lut), a natural flavonoid extracted from plants, possesses several beneficial bioactivities. However, little is known about its anti-inflammatory properties. This study was designed to investigate the anti-inflammatory effects and underlying molecular mechanisms of luteolin in LPS plus IFN-γ activated RAW264.7 macrophages (M1 macrophages). RAW264.7 cells were induced to M1 polarization by LPS plus IFN-γ, accompanied with luteolin at non-cytotoxic doses. The results showed that the M1 macrophages presented dendrites characteristic with synapsis. In addition, luteolin can inhibit inflammation by modulating the expression of mediators, such as iNOS, IL-1β, IL-6, TNF-α, and CD86, whose expression was increased remarkably in the activated RAW264.7 cells. More importantly, the proteins p-STAT3-ser727 and p-STAT3-tyr705, which involved in inflammatory pathways, exhibited a dose-dependent degradation in M1 macrophages after treatment with luteolin. In conclusion, luteolin have potential applications as a functional food component in regulating inflammatory responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 32, May 2017, Pages 123-130
نویسندگان
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