کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137166 | 1494534 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of luteolin on inflammatory responses in RAW264.7 macrophages activated with LPS and IFN-γ
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کلمات کلیدی
STAT3LPSTNFRAW264.7 macrophageIFN-γiNOSIL-1βSTAT - آمارinterferon-γ - اینترفرون-γInterleukin-1β - اینترلوکین-1βcluster of differentiation - خوشه تمایزinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییtumour necrosis factor - عامل نکروز تومورLuteolin - لوتئولینlipopolysaccharide - لیپوپلی ساکاریدSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیInflammatory response - واکنش التهابیhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Luteolin (Lut), a natural flavonoid extracted from plants, possesses several beneficial bioactivities. However, little is known about its anti-inflammatory properties. This study was designed to investigate the anti-inflammatory effects and underlying molecular mechanisms of luteolin in LPS plus IFN-γ activated RAW264.7 macrophages (M1 macrophages). RAW264.7 cells were induced to M1 polarization by LPS plus IFN-γ, accompanied with luteolin at non-cytotoxic doses. The results showed that the M1 macrophages presented dendrites characteristic with synapsis. In addition, luteolin can inhibit inflammation by modulating the expression of mediators, such as iNOS, IL-1β, IL-6, TNF-α, and CD86, whose expression was increased remarkably in the activated RAW264.7 cells. More importantly, the proteins p-STAT3-ser727 and p-STAT3-tyr705, which involved in inflammatory pathways, exhibited a dose-dependent degradation in M1 macrophages after treatment with luteolin. In conclusion, luteolin have potential applications as a functional food component in regulating inflammatory responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 32, May 2017, Pages 123-130
Journal: Journal of Functional Foods - Volume 32, May 2017, Pages 123-130
نویسندگان
Shuxia Wang, Meng Cao, Shuhang Xu, Jiaming Zhang, Zhiguo Wang, Xiaodong Mao, Xiaoming Yao, Chao Liu,