Heterolytic OO bond cleavage: Functional role of Glu113 during bis-Fe(IV) formation in MauG

The bis-Fe(IV) intermediate of the diheme enzyme MauG is a lynchpin species in the biogenesis of the tryptophan tryptophylquinone cofactor. A heterolytic OO bond cleavage reaction assisted by a distal glutamate residue is found to be critical for the formation of this high-valence intermediate.156