Complexation of insecticide chlorantraniliprole with human serum albumin: Biophysical aspects

► Our study highlights for the first time how binding dynamics can predominate for the new diamide insecticide, chlorantraniliprole. ► Chlorantraniliprole is situated within subdomain IIIA, Sudlow's site II, which is the same as that of indole-benzodiazepine site. ► Biophysical and molecular modeling approaches are useful to resolve the ligand interaction with biomacromolecule. ► It serves as a protective device in binding and in inactivating potential toxic compounds to which the body is exposed.