کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433786 1508996 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma
ترجمه فارسی عنوان
پیکلایتکسل دیمر برای جمع آوری نانومواد برای درمان سرطان دهانه رحم
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

Poor water solubility and adverse side effects pose a challenge for clinical application of paclitaxel (PTX). In this work, a series of PTX dimers are synthesized by coupling two PTX molecules with dicarboxylic acids. As-synthesized PTX dimers form stable nanoparticles in aqueous solution without using any surfactants or adjuvants, and the solubility of PTX in water increases by 2500-fold compared to that of free PTX. These nanoparticles with high content of PTX are internalized by cancer cells and exhibit comparable cytotoxicity with Taxol. Furthermore, when the PTX dimers are incorporated into methoxypoly(ethylene glycol)2K-block-poly(d, l-lactide)2K (PEG-PDLLA) micelles, the loading content of PTX dimers is as high as 85 wt%. The formed nanoparticles possess the high stability in biological conditions. Both in vitro and in vivo experiments show that these (PTX dimer)/PEG-PDLLA formulations possess effective cellular uptake and potent cytotoxicity, and exhibit reduced systemic toxicity and enhanced antitumor efficacy towards human cervical tumor. We believe these PTX dimers-based nanoparticles would be an alternative formulation for PTX, and such drug dimer assembling behaviors could be extended to other therapeutic agents.

PTX dimers could be self-assemble into stable nanoparticles in aqueous solution. These PTX dimer-based nanomedicines possess effective cellular uptake, potent cytotoxicity, reduced systemic toxicity and enhanced antitumor efficacy.70

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 254, 28 May 2017, Pages 23-33
نویسندگان
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