کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5435106 1509145 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization of two biopolymer-based oral films for the delivery of bioactive molecules
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Optimization of two biopolymer-based oral films for the delivery of bioactive molecules
چکیده انگلیسی


- Experimental design allowed obtaining optimized CMC and gelatin films.
- Quality-by-design was assured by performing an experimental design.
- Technological influence of excipients on characteristics of films was assessed.
- CMC promotes controlled release and gelatin promotes immediate release.

An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay revealed that GelTA was more effective in controlling caffeine release since maximum caffeine release (97.4% ± 0.95) after 20 min. On the other hand, CMC is better indicated for immediate release since maximum caffeine release (81.1% ± 2.14) occurred after 4 min. Simulation of gastrointestinal tract with ex vivo permeability assay was in accordance with USP dissolution assay (42.0% ± 7.79 and 15.3% ± 4.0 of caffeine released from CMC and GelTA oral films (OF), respectively, permeated porcine intestinal mucosa after 120 min). CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 76, 1 July 2017, Pages 171-180
نویسندگان
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