کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5495700 | 1529394 | 2017 | 7 صفحه PDF | دانلود رایگان |
AimTo evaluate toxicity of high conformal image-guided radiotherapy of the prostate bed.BackgroundRadiotherapy of the prostate bed has a pivotal role in the post-operative and salvage settings, but few clinical data are available on the use of daily image guidance in combination with highly conformal techniques, and data on long-term results are lacking.Materials and methodsWe analyzed 118 patients irradiated on the prostate bed using conformal plans processed with a micro-multileaf collimator, and daily checking treatment set-up with a cone-beam CT system. Correlation between toxicity and clinical-dosimetric parameters was assessed by the Cox regression model and log-rank test. Survival analyses were performed with the Kaplan-Meier method.ResultsMedian follow-up was 54.08 months. Late grade â¥2 gastro-intestinal (GI) and genito-urinary (GU) toxicity were 3.4% and 4.2%, respectively. Actuarial 4-year late grade â¥2 GI and GU toxicities were 4% and 6%, respectively. Four-year relapse-free survival was 87%. At log-rank test, acute grade â¥2 GI toxicity is associated with the use of antihypertensives (p = 0.03), and there is a trend toward significance between the use of anticoagulants and late grade â¥2 GI toxicity (p = 0.07). At Cox analysis, acute grade â¥2 GU toxicity is correlated with the percentage of bladder volume receiving more than 65 Gy (p = 0.02, HR 1.87 CI 1.25-2.8), and the maximal dose to the rectum is correlated to the development of late grade â¥2 GI toxicity (p = 0.03, HR 2.75 CI 1.10-6.9).ConclusionsConformal volumetric image-guided radiotherapy of the prostate bed leads to low toxicity rates.
Journal: Reports of Practical Oncology & Radiotherapy - Volume 22, Issue 1, JanuaryâFebruary 2017, Pages 64-70