کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5532096 1549615 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurofibromatosis type 1 and multiple sclerosis: Genetically related diseases
ترجمه فارسی عنوان
نوروفیبروماتوز نوع 1 و مولتیپل اسکلروزیس: بیماری های مرتبط با ژنتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Neurofibromatosis type I (NF1) is an autosomal dominant disorder with involvement of both the cutaneous and nervous systems. Patients are susceptible to neurological complication in the form of tumors of the brain and spinal cord. Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelinated axons in the central nervous system. Unlike MS, none of the neurological complications of NF1 is demyelinating. The association of these two diseases in the same patient is rare and could be genetically related. Early detection of the presence of MS in patients with NF1 is of utmost importance as treatment will certainly decrease further neurological disability. Here we report the first Egyptian lady with this association.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Medical Human Genetics - Volume 18, Issue 3, July 2017, Pages 295-298
نویسندگان
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