کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5533429 1550394 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleNovel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Original articleNovel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method
چکیده انگلیسی


- Applied a pleiotropic cFDR method to GWAS data to identify potential novel variants for complex trait.
- Identified 2 potential pleiotropic variants for body mass index and coronary artery disease.
- Identified 2 and 11potential novel variants for body mass index and coronary artery disease, respectively.

Genome-wide association studies (GWAS) have been successfully applied in identifying single nucleotide polymorphisms (SNPs) associated with body mass index (BMI) and coronary heart disease (CAD). However, the SNPs to date can only explain a small percentage of the genetic variances of traits. Here, we applied a genetic pleiotropic conditional false discovery rate (cFDR) method that combines summary statistic p values from different multi-center GWAS datasets, to detect common genetic variants associated with these two traits. The enrichment of SNPs associated with BMI and CAD was assessed by conditional Q-Q plots and the common variants were identified by the cFDR method. By applying the cFDR level of 0.05, 7 variants were identified to be associated with CAD (2 variants being novel), 34 variants associated with BMI (11 variants being novel), and 3 variants associated with both BMI and CAD (2 variants being novel). The SNP rs653178 (ATXN2) is noteworthy as this variant was replicated in an independent analysis. SNP rs12411886 (CNNM2) and rs794356 (HIP1) were of note as the annotated genes may be associated with processes that are functionally important in lipid metabolism. In conclusion, the cFDR method identified novel variants associated with BMI and/or CAD by effectively incorporating different GWAS datasets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 112, November 2017, Pages 1-7
نویسندگان
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