کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5550585 | 1557296 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Relative humidity and temperature show coupled effect on powder surface caking.
- Irreversible caking is formed in PVP and HPC at 75% relative humidity (RH).
- The critical glass transition RH for PVP at 25 °C and 45 °C are 63% and 53%.
- The critical glass transition RH for HPC at 25 °C and 45 °C are 61% and 50%.
- Ball indentation is an effective method for assessment of powder surface caking.
Powder caking is a ubiquitous problem, which could significantly decrease product quality and lead to economic losses. Hence it is important to know the conditions under which it occurs. The caking behaviour of three powder materials (PVP, HPC and CaHPO4) has been investigated by the ball indentation method (BIM) as affected by relative humidity (RH), temperature and time. The resistance to powder flow, as indicated by the hardness is measured by a ball indenting the powder bed surface. The surface hardness increases with increasing RH and temperature, indicating caking of the powder bed. Moreover, the temperature and RH show a coupled effect on powder caking. Irreversible caking is formed in PVP and HPC at 75% RH; the particles coalesce and the volume of powder bed is significantly reduced with time. However, the caking of CaHPO4 is reversible. To examine the caking mechanism of PVP and HPC, the critical glass transition RH is determined at 25 °C and 45 °C. The values are 63% and 53% RH for PVP and 61% and 50% RH for HPC, respectively. The glass transition moisture content in the ball indentation experiments is comparable with that determined by the dynamic vapor sorption measurement. BIM could be a fast and effective method for the assessment of powder surface caking.
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Journal: International Journal of Pharmaceutics - Volume 521, Issues 1â2, 15 April 2017, Pages 61-68