کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560803 1562032 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal environmental chemical exposures and longitudinal patterns of child neurobehavior
ترجمه فارسی عنوان
قرار گرفتن در معرض مواد شیمیایی زیست محیطی و الگوهای طولی عصبی کودک
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Prenatal BPA and PBDE exposures were associated with more externalizing behaviors.
- Prenatal PBDE exposure was associated with poorer cognitive abilities.
- The association between PBDE and cognitive abilities strengthened as children aged.
- Reproducibility of neurobehavioral measures from age 1-8 years varied by domain.

BackgroundPrenatal chemical exposures may adversely affect neurodevelopment, but few studies have examined the persistence of these associations. We examined whether associations between prenatal bisphenol A (BPA) or polybrominated diphenyl ether (PBDE) exposures persist or resolve as children age.MethodsWe followed 346 mother-child pairs (enrolled 2003-2006) from Cincinnati, OH from pregnancy until children were 8 years old. We measured BPA in urine collected at 16 and 26 weeks gestation and PBDE-47 in serum collected at 16 weeks gestation. We administered repeated measures of children's behavior, mental/psychomotor development, and IQ from ages 1-8 years. We determined if associations of BPA or PBDE-47 with child neurobehavior persisted or resolved as children aged using linear mixed models and estimated neurobehavioral measure reproducibility using intraclass correlation coefficients (ICCs).ResultsHigher BPA in girls and higher PBDE-47 in both boys and girls were associated with more externalizing behaviors; these associations persisted from ages 2-8 years (exposure × age interaction p-values ≥ 0.36). Higher PBDE-47 concentrations were associated with decreases in MDI from ages 1-3 years (PBDE-47 x age interaction p-value = 0.03) and persistently lower IQ at ages 5 and 8 years (PBDE-47 × age interaction p-value = 0.56). Mental/psychomotor abilities had fair reproducibility from ages 1-3 years (ICCs ∼ 0.4), cognitive abilities from ages 5 to 8 years had excellent reproducibility (ICCs = 0.7-0.8), and parent-reported behaviors from ages 2-8 years had poor to good reproducibility (ICCs = 0.38-0.59).ConclusionsPrenatal BPA and PBDE-47 concentrations were persistently associated with more externalizing behaviors. PBDE-47 concentrations were inversely associated with cognitive abilities that strengthened over time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 62, September 2017, Pages 192-199
نویسندگان
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