کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5656860 1589656 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Propofol sedation substantially increases the caloric and lipid intake in critically ill patients
ترجمه فارسی عنوان
آرام بخش پروپوفول به میزان قابل توجهی مصرف کالری و چربی در بیماران مبتلا به بیماری را افزایش می دهد
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی


- Continuous propofol sedation results in a significant fat and energy delivery.
- A concentrated 2% solution reduces the unwanted intake of fat.
- Monitoring real daily intakes of fat enables adjusting nutrition therapy and prevents an unbalanced diet.
- Triacylglycerol monitoring once or twice weekly assists the detection of impending fat overload.
- Propofol sedation over several days may have unwanted metabolic consequences on catabolism.

ObjectiveThe amount of lipid delivered to patients varies considerably depending on the non-nutritional intake from sedation, and on the feeding solution. The aim of this study was to quantify the magnitude and proportion of lipids and energy provided from propofol sedation in intensive care unit (ICU) patients.MethodsThis was a retrospective analysis of prospectively collected data in consecutive patients admitted to the ICUs of two university hospitals. Inclusion criterion included an ICU stay >5 d. Data were collected for a maximum of 10 d. Propofol sedation using 1% or 2% propofol solutions was defined as >100 mg/d. Nutritional management was per protocol in both centers, recommending enteral feeding. Data are shown as means ± standard deviation.ResultsIn all, 701 admissions (687 patients, ages 59 ± 16 y, SAPS II 51 ± 17) and 6485 d, including 3484 propofol sedation days were analyzed. Energy targets were 1987 ± 411 kcal/d; mean energy delivery was 1362 ± 811 kcal/d (70% ± 38% of prescription) including propofol and dextrose. Enteral feeding dominated (75% of days) and progressed similarly in both ICUs. Mean propofol sedation dose was 2045 ± 1650 mg/d, resulting in 146 ± 117 kcal/d. Fat from propofol constituted 17% of total energy (up to 100% during the first days). Fat delivery (40 ± 23 g/d: maximum 310 g/d) was significantly increased by the combination of propofol sedation, the 1% solution, and high-fat-containing feeds. In survivors, high-fat proportion was associated with prolonged ventilation time (P < 0.0001).ConclusionPropofol sedation resulted in large doses of lipids being delivered to patients, some receiving pure lipids during the first days. As the metabolic effects of high proportions of fat are unknown, further research is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 42, October 2017, Pages 64-68
نویسندگان
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