کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5656892 1589659 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels
چکیده انگلیسی


- The present study investigated the locomotor activity, energy metabolism, and lipid metabolism of aged mice fed coffee.
- Aged mice that consumed either caffeine-containing regular or decaffeinated coffee had decreased plasma-free fatty acids and increased adenosine triphosphate and total phosphorylated mammalian target of rapamycin, which is closely associated with aging, in the liver.
- Consumption of regular coffee increased the food and water intake, locomotor activity, volume of oxygen consumption, and respiration exchange ratio of aged mice.
- Coffee, one of the world's most consumed beverages, has potential antiaging effects.

ObjectiveCoffee, one of the world's most consumed beverages, has many benefits. Some studies have reported the effects of coffee on aging. The aim of this study was to investigate the locomotor activity, energy metabolism, and lipid metabolism of aged (20-mo-old) mice given coffee.MethodsAged C57 BL/6 NCr mice were divided into three groups: controls that were not given coffee (n = 9), a group that received 0.1% caffeinated coffee (n = 9), and a group that received 0.1% decaffeinated coffee (n = 9). This regimen continued for 17 wk until mice reached the age of 24 mo.ResultsRegular and decaffeinated coffee consumption decreased plasma-free fatty acid levels, increased hepatic adenosine triphosphate content, and decreased total mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) protein content in the liver. However, no differences were found in the protein or activity levels of Akt, adenosine monophosphate-activated protein kinase (AMPK), p70 S6 kinase, or sterol regulatory element-binding protein 1, proteins that are upstream or downstream of the mTOR complex 1 (mTORC1)-related pathways. Regular coffee consumption increased food and water intake, locomotor activity, the volume of carbon dioxide production, and the respiration exchange ratio.ConclusionRegular and decaffeinated coffee consumption decreased hepatic total mTOR and p-mTOR levels independently of Akt and AMPK pathways in aged mice. Because decreased mTORC1 activity is known to have antiaging effects, coffee consumption during old age may retard aging. Moreover, coffee consumption by the aged population had a positive effect on behavioral energy and lipid metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 38, June 2017, Pages 1-8
نویسندگان
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