کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736264 | 1613226 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute intravenous administration of dietary constituent theanine suppresses noxious neuronal transmission of trigeminal spinal nucleus caudalis in rats
ترجمه فارسی عنوان
تجویز حاد تزریقی تینین مضر در رژیم غذایی، انتقال نورونهای عضلانی هسته قاعده ترامینال را در موش های صحرایی سرکوب می کند
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
N-methyl-d-aspartatespinal trigeminal nucleus caudalisα-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acidtrigeminal spinal nucleus caudalisSpVcWDRNMDAAMPADRGSSSdorsal root ganglion - گانگلیون ریشه پشتیγ-aminobutyric acid - اسید γ-آمینوبوتیریکTheanine - تانینanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceCAM - ساخت به کمک کامپیوترsuperior sagittal sinus - سینوسی سرایتتال برترsingle unit recording - ضبط تک واحدcomplementary and alternative medicine - طب مکمل و جایگزینwide dynamic range - طیف گسترده ای پویاnociception - غربالگریGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Theanine is a non-dietary amino acid linked to the modulation of synaptic transmission in the central nervous system, although the acute effects of theanine in vivo, particularly on nociceptive transmission in the trigeminal system, remain to be determined. The present study investigated whether acute intravenous theanine administration to rats attenuates the excitability of wide dynamic range (WDR) spinal trigeminal nucleus caudalis (SpVc) neurons in response to nociceptive and non-nociceptive mechanical stimulation in vivo. Extracellular single unit recordings were made from 15 SpVc neurons in response to orofacial mechanical stimulation of pentobarbital-anesthetized rats, and responses to non-noxious and noxious mechanical stimuli were analyzed. The mean firing frequency of SpVc WDR neurons in response to all mechanical stimuli was dose-dependently inhibited by theanine (10, 50, and 100Â mM, i.v.) with the maximum inhibition of discharge frequency reached within 5Â min. These inhibitory effects were reversed after approximately 10Â min. The relative magnitude of theanine's inhibition of SpVc WDR neuronal discharge frequency was significantly greater for noxious than non-noxious stimulation. Iontophoretic application of l-glutamate induced the mean firing frequency of SpVc WDR neuron responding to noxious mechanical stimulation was also inhibited by intravenous administration of 100Â mM theanine. These results suggest that acute intravenous theanine administration suppresses glutaminergic noxious synaptic transmission in the SpVc, implicating theanine as a potential complementary and alternative therapeutic agent for the treatment of trigeminal nociceptive pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 131, May 2017, Pages 70-77
Journal: Brain Research Bulletin - Volume 131, May 2017, Pages 70-77
نویسندگان
Shiori Takehana, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu, Mamoru Takeda,