کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5764243 | 1625920 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus)
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
TRHRPBDEsHypothalamus-pituitary-thyroid axishpfDeiodinaseTPOS.E.M.PCPDCNPDIOTTRDPFDCPThyrotropin-releasing hormone receptorLOQ2,4-D - 2،4-D2,4-dichlorophenol - 2،4-dichlorophenol2,4-dichlorophenoxyacetic acid - 2،4-dichlorophenoxyacetic اسید3,5,3′-triiodothyronine - 3،5،3'-triiodothyronineEDCs - EDC هاGC–MS - GC-MSNiS - NISTHs - THSEndocrine disruption - اختلالات غدد درون ریزTTR, Transthyretin - ترانستیرتینELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاThyroperoxidase - تیروپراکسیدازthyroxine - تیروکسینstandard error of the mean - خطای استاندارد میانگینPolybrominated diphenyl ethers - دیفنیل اتر پلی بوروندیdays post-fertilization - روز پس از لقاحhours post-fertilization - ساعت پس از لقاحsodium-iodide symporter - سدیم یدیدlimit of quantification - محدودیت اندازه گیریHPT axis - محور HPTHypothalamic-pituitary-thyroid axis - محور هیپوتالاموس-هیپوفیز-تیروئیدEndocrine-disrupting chemicals - مواد شیمیایی خرابکار غدد درون ریزChinese rare minnow - نان چینی نینجاThyroid hormones - هورمونهای تیروئیدیPentachlorophenol - پنتا کلروفنلgas chromatography/mass spectrometry - کروماتوگرافی گاز / طیف سنج جرمیthyroid hormone receptor - گیرنده هورمون تیروئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, to evaluate embryonic toxicity and the thyroid-disrupting effects of 2,4-dichloro-6-nitrophenol (DCNP), embryos and adults of Chinese rare minnow (Gobiocypris rarus) were exposed to 2, 20, and 200 μg/L DCNP. In the embryo-larval assay, increased percentages of mortality and occurrence of malformations, decreased percentage of hatching, and decreased body length and body weight were observed after DCNP treatment. Moreover, the whole-body T3 levels were significantly increased at 20 and 200 μg/L treatments, whereas the T4 levels were markedly decreased significantly (p < 0.05) for all DCNP concentrations. In the adult fish assay, plasma T3 levels were significantly increased whereas plasma T4 levels were significantly reduced in the fish treated with 20 and 200 μg/L (p < 0.05). In addition, DCNP exposure significantly changed the transcription levels of thyroid system related genes, including dio1, dio2, me, nis, tr, and ttr. The increased responsiveness of thyroid hormone and mRNA expression levels of thyroid system related genes suggested that DCNP could disrupt the thyroid hormone synthesis and transport pathways. Therefore, our findings provide new insights of DCNP as a thyroid hormone-disrupting chemical.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 185, April 2017, Pages 40-47
Journal: Aquatic Toxicology - Volume 185, April 2017, Pages 40-47
نویسندگان
Rui Chen, Lilai Yuan, Jinmiao Zha, Zijian Wang,