کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5826802 | 1558908 | 2016 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice
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کلمات کلیدی
ZM241385TRPV1ADPNMDAN-methyl-d-aspartatePNPDPCPXAMPAGMPIMPA2AHGPRTInosineAMPPurinesAOPCPGTPMPESCH582618-PT(±)-1-aminocyclopentane-trans-1,3-dicarboxylic acid8-Cyclopentyl-1,3-dipropylxanthine - 8-Cyclopentyl-1،3-dipropylxanthineDMSO - DMSOAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPadenosine diphosphate - آدنوزین دی فسفاتadenosine monophosphate - آدنوزین مونوفسفرهi.t. - آی تی.α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکintrathecal - اینتراکتالtrans-ACPD - ترانس ACPDGDP - تولید ناخالص ملیMaximum possible effect - حداکثر اثر ممکنPain - دردCNS - دستگاه عصبی مرکزیDimethyl sulfoxide - دیمتیل سولفواکسیدcentral nervous system - سیستم عصبی مرکزیSpinal cord - طناب نخاعیnociception - غربالگریCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیInosine monophosphate - مونوفسفات inosinehypoxanthine-guanine phosphoribosyl transferase - هیپوکسانتین-گوانین فسفریبوسیل ترانسفرازPurine nucleoside phosphorylase - پورین نوکلئوزید فسفوریلاhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراGuanosine monophosphate - گوئنوسین مونوفسفرهGuanosine triphosphate - گوانوزین تری فسفاتguanosine diphosphate - گوانوزین دی فسفاتGuanine - گوانین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is well known that adenine-based purines exert multiple effects on pain transmission. Recently, we have demonstrated that guanine-based purines may produce some antinociceptive effects against chemical and thermal pain in mice. The present study was designed to investigate the antinociceptive effects of intrathecal (i.t.) administration of inosine or guanine in mice. Additionally, investigation into the mechanisms of action of these purines, their general toxicity and measurements of CSF purine levels were performed. Animals received an i.t. injection of vehicle (30Â mN NaOH), inosine or guanine (up to 600Â nmol) and submitted to several pain models and behavioural paradigms. Guanine and inosine produced dose-dependent antinociceptive effects in the tail-flick, hot-plate, intraplantar (i.pl.) glutamate, i.pl. capsaicin and acetic acid pain models. Additionally, i.t. inosine inhibited the biting behaviour induced by spinal injection of capsaicin and i.t. guanine reduced the biting behaviour induced by spinal injection of glutamate or AMPA. Intrathecal administration of inosine (200Â nmol) induced an approximately 115-fold increase on CSF inosine levels. This study provides new evidence on the mechanism of action of extracellular guanine and inosine presenting antinociceptive effects following spinal administration. These effects seem to be related, at least partially, to the modulation of A1 adenosine receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 772, 5 February 2016, Pages 71-82
Journal: European Journal of Pharmacology - Volume 772, 5 February 2016, Pages 71-82
نویسندگان
Enderson D. de Oliveira, Cristhine Schallenberger, Ana Elisa Böhmer, Gisele Hansel, Aécio C. Fagundes, Michael Milman, Marcos D.P. Silva, Jean P. Oses, Lisiane O. Porciúncula, LuÃs V. Portela, Elaine Elisabetsky, Diogo O. Souza, André P. Schmidt,