Rivastigmine reduces “likely to use methamphetamine” in methamphetamine-dependent volunteers

► Much work remains in identifying a pharmacotherapy for METH dependence. ► Compounds that increase ACh may attenuate subjective effects produced by METH. ► The effects of rivastigmine were evaluated after METH administration in the lab. ► Rivastigmine significantly attenuated “Likely to Use METH”. ► Cholinesterase inhibitors warrant consideration as treatments for METH dependence.