Effects of choline on sodium arsenite-induced neural tube defects in chick embryos

► We first demonstrated that CHO at low dose protected against SA-induced NTDs. ► We studied the effects of different dose CHO on sodium arsenite-induced NTDs. ► Our finding may provide an effective preventive to protect SA-induced NTDs. ► We provide new insights into the relation of environmental pollutant and micronutrient during the early embryo development.