Angelicae Gigantis Radix regulates mast cell-mediated allergic inflammation in vivo and in vitro

► Angelicae gigantis Radix (AG) has anti-allergy effects on in vivo and in vitro models. ► AG reduced chemical-induced PCA and histamine release. ► AG reduced DNFB-induced contact hypersensitivity in mice. ► AG inhibited the production of interleukin (IL)-6, IL-8, and TNF-α in HMC-1 cell. ► AG inhibited the activation of JNK and NF-κB in PMACI-stimulated HMC-1 cell.