کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858434 1562167 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis
ترجمه فارسی عنوان
قرار گرفتن در معرض فلوکونازول و خطر ناهنجاری های مادرزادی در پسران: بررسی منظم و متاآنالیز
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی

Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, mostly during the reproductive age, and recurrence rate is about 50%. Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased. Thus, we aimed to examine the risk of congenital malformations in the offspring of women exposed to fluconazole in the first trimester of pregnancy. The rate for overall malformations was 1.10 (95% CI 0.98-1.25), for heart defect was 1.29 (95% CI 1.05-1.58), for craniofacial defects was 1.25 (95% CI 0.88-1.77), and for limb/musculoskeletal defects was 0.82 (95% CI 0.59-1.13). In conclusion, the use of fluconazole in the first trimester does not appear to increase the overall risk for congennital malformations. More studies are needed to address the potential increased rate of heart defects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 52, April 2015, Pages 78-82
نویسندگان
, , ,