The solid-state and morphological characteristics of particles generated from solution-based metered dose inhalers: Influence of ethanol concentration and intrinsic drug properties

- Particle size of solution pressurized metered dose inhaler is affected by initial droplet diameter and drug concentration.
- Aerosol performance is governed by droplet drying time.
- Solid state of produced aerosols is determined by glass transition temperature of a drug.
- Final structure of the aerosol is dependent on ethanol concentration and droplet drying kinetics.