کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6018846 1186529 2012 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy
چکیده انگلیسی
► A significant portion of patients with epilepsy are resistant to medical treatment. ► Understanding mechanisms of resistance is needed for developing more efficacious treatments. ► In epileptic rats, EEG video/monitoring was used to evaluate response to phenobarbital. ► About 50% of the rats were resistant, while other rats responded with significant seizure suppression. ► Several factors that may be relevant for resistance were compared in responders and nonresponders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 234, Issue 1, March 2012, Pages 70-84
نویسندگان
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