کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6089001 1208531 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basic nutritional investigationPreparation of iron-enriched baker's yeast and its efficiency in recovery of rats from dietary iron deficiency
ترجمه فارسی عنوان
تحقیقات پایه تغذیه آماده سازی مخمر نانوایی غنی شده با آهن و کارایی آن در بهبودی موش صحرایی از کمبود آهن
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی


- Iron-enriched yeast was prepared by cultivation of yeast cells at different iron concentrations and the best concentration was determined with no effect of yeast growth or baking properties.
- Anemic rats were fed different diets containing either inorganic iron salt or iron-enriched yeast as the iron source.
- Feeding efficiency and different hematologic incidences were followed up for all groups.
- Histologic study was performed for liver, heart, kidney, and spleen tissues in all groups.
- Feeding anemic rats with supplemented yeast leads to better results in recovery from iron deficiency compared with other diets containing inorganic iron salt as the iron source.

ObjectivesIron is an important mineral, essential for the health and function of mammalian cells. Despite its key role, iron deficiency in humans is common worldwide, often leading to significant health issues within the population. The aim of this study was to evaluate the potential of using iron-enriched baker's yeast as a source of iron, especially for the protection and recovery from conditions related to anemia.MethodsIron-enriched yeast was prepared by cultivating cells on basal medium comprising different iron concentrations. The effects of iron supplementation on animal health were assessed by feeding anemic rats with a variety of diets containing either inorganic iron or iron-enriched yeast. Body weight, iron bioavailability, blood parameters, and the activity of iron-containing enzymes (catalase) were studied.ResultsIron accumulation in yeast cells increased with iron concentration, reaching a maximum of 15 mg/g when 32 mM iron was applied. Rat groups fed iron-enriched yeast had the highest feed efficiency, iron bioavailability, and hemoglobin concentration. The source of iron supplementation influenced catalase activity in kidney tissues, increasing from 70 U/g tissue in anemic rats to 90 U/g tissue (inorganic iron salt), 110 U/g tissue (inorganic iron salt and non-enriched dry yeast), 145 U/g tissue (iron-enriched yeast 15 mg/g iron) and 115 U/g tissue (iron-enriched yeast 30 mg/g iron). The histologic study of tissues from liver, kidney, heart, and spleen of rats from different groups showed that the damage observed in tissues of anemic rats, was not observed after feeding with iron-enriched yeasts.ConclusionThe results demonstrated that ingestion of iron-enriched yeast is more efficient than inorganic treatment in recovery from iron deficiency, including tissue recovery in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 31, Issue 9, September 2015, Pages 1155-1164
نویسندگان
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