کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6125991 | 1221185 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Profiling of peripheral blood mononuclear cells does not accurately predict the bronchiolitis obliterans syndrome after lung transplantation
ترجمه فارسی عنوان
پروتئین سلولهای تک هسته ای خون محیطی دقیقا پیشآزمون سندرم برونشیولیت انقباض پس از پیوند ریه نیست
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کلمات کلیدی
FEV1PBMCBOSROCLTXAUC - AUCHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیBALF - بافتForced expiratory volume in 1 s - حجم انقباض اجباری در 1 ثانیهAcute rejection - رد حادcentral memory T cells - سلول های T حافظه مرکزیnatural killer T cells - سلول های T قاتل طبیعیperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیeffector memory T cells - سلول های حافظه اثر گذار TNaive T cells - سلول های غیر طبیعی TNK cells - سلولهای NKNKT cells - سلولهای NKTNatural killer cells - سلولهای کشنده طبیعیBronchiolitis obliterans syndrome - سندرم Bronchiolitis obliteransBronchoalveolar lavage fluid - مایع لارو برونکلوفلورarea under the curve - منطقه تحت منحنیLung transplantation - پیوند ریهreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
After lung transplantation (LTx), circulating mononuclear cell composition and their subsets may be predictive for the bronchiolitis obliterans syndrome (BOS). We investigated the cellular composition in patients developing BOS, or not, by analyzing peripheral blood taken at multiple time points after transplantation. PBMCs of 11 BOS and 39 non-BOS patients were analyzed by FACS for monocytes, dendritic cells, NK-, NKT-, B- and T cells as well as B- and T cell subsets. Analysis of blood samples taken monthly during the first year post-LTx showed that circulating NK, NKT and dendritic cell percentages were not indicative of BOS development, whereas increases in T cells, monocytes and lowered fractions of B cells were related to BOS development. B- and T cell subset analysis at month 5 post-LTx indicated that IgM+IgDÂ â memory B cells and central memory CD8Â + T cells were decreased, whereas NKT cells were increased in BOS patients compared to non-BOS patients. Prior to BOS diagnosis, the composition of specific mononuclear cells on a group level differs from patients remaining BOS free. However, given the overlap in percentages of cellular frequencies between the patient groups investigated, this analysis does not allow prediction or risk stratification for development of BOS in individual patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Brought to you by:GAYATRI VIDYA PARISHAD COLLEGE OF ENGINEERING for Women Renewal due by 31 Dec 2017
Journal: Transplant Immunology - Brought to you by:GAYATRI VIDYA PARISHAD COLLEGE OF ENGINEERING for Women Renewal due by 31 Dec 2017
نویسندگان
Kevin Budding, Eduard A. van de Graaf, Annelieke W.M. Paantjens, Tineke Kardol-Hoefnagel, Johanna M. Kwakkel-van Erp, Diana A. van Kessel, Henderikus G. Otten,