کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
6450484 1416117 2018 27 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
ReviewUnraveling the mechanistic effects of electric field stimulation towards directing stem cell fate and function: A tissue engineering perspective
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
ReviewUnraveling the mechanistic effects of electric field stimulation towards directing stem cell fate and function: A tissue engineering perspective
چکیده انگلیسی

Electric field (EF) stimulation can play a vital role in eliciting appropriate stem cell response. Such an approach is recently being established to guide stem cell differentiation through osteogenesis/neurogenesis/cardiomyogenesis. Despite significant recent efforts, the biophysical mechanisms by which stem cells sense, interpret and transform electrical cues into biochemical and biological signals still remain unclear. The present review critically analyses the variety of EF stimulation approaches that can be employed to evoke appropriate stem cell response and also makes an attempt to summarize the underlying concepts of this notion, placing special emphasis on stem cell based tissue engineering and regenerative medicine. This review also discusses the major signaling pathways and cellular responses that are elicited by electric stimulation, including the participation of reactive oxygen species and heat shock proteins, modulation of intracellular calcium ion concentration, ATP production and numerous other events involving the clustering or reassembling of cell surface receptors, cytoskeletal remodeling and so on. The specific advantages of using external electric stimulation in different modalities to regulate stem cell fate processes are highlighted with explicit examples, in vitro and in vivo.

The effect of EF in regulating the expression of a wide panel of genes that are involved in the process of stem cell migration, and functional differentiation towards angiogenic, neurogenic, cardiomyogenic and osteogenic lineage.178

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 150, January 2018, Pages 60-86
نویسندگان
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