Preparation and characterization of Fe3O4-Ag2O quantum dots decorated cellulose nanofibers as a carrier of anticancer drugs for skin cancer

- Fe3O4-Ag2O QDs/Cellulose fibers nanocomposites were synthesized for carriers of anticancer drug.
- The nanocomposites have ferromagnetic properties.
- Drug release in 24 h-78.94% and in 30 h-63.84% was carried out for two drugs.
- The synthesized samples showed moderate antioxidant and Cytotoxicity activities.

The Best performance drug delivery systems designed with Fe3O4-Ag2O quantum dots decorated cellulose nanofibers which that grafted with Etoposide and Methotrexate. Morphology properties were characterized by Scanning and Transmittance electron microscopy. The crystalline structure of prepared sample was evaluated using by X-ray diffraction. The vibrating sample magnetometer analysis was used for magnetic behavior of samples. The size distributions of Fe3O4-Ag2O QDs/Cellulose fibers nanocomposites indicate that the average diameter was 62.5 nm. The Saturation magnetization (Ms) indicates the Fe3O4-Ag2O QDs/Cellulose fibers nanocomposites have ferromagnetic properties in nature. For make carrier, the Iron and Silver should be binds to cellulose nanofibers and to drug molecules and observe in UV-vis spectroscopy. The drug release kinetics was studied in vitro as spectrophotometrically. The release of Etoposide and Methotrexate were carried out with a constant speed, and the equilibrium reached at 24 and 30 h with a total amount 78.94% and 63.84%, respectively. The results demonstrated that the obtained Fe3O4-Ag2O quantum dots/cellulose fibers nanocomposites could be applied for drug delivery systems. Cytotoxicity and antioxidant study confirmed the activity of the drug incorporated in nanocomposites. In addition, the cytotoxicity of drug was increased when loaded on nanocomposites, compared to pure Fe3O4-Ag2O quantum dots/cellulose fibers nanocomposites.