Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT

A novel single near infrared (NIR) laser-induced multifunctional theranostic nanoplatform based on single component black titania (B-TiO2−x) has been successfully constructed for in vivo effective dual-modal imaging-guided cancer therapy for the first time. This highly biocompatible B-TiO2−x with PEGylation shows broad optical absorption property ranging from NIR to ultraviolet (UV), and has been demonstrated both in vitro and in vivo, to be capable of serving as a new multifunctional theranostic nanoplatform for infrared thermal/photoacousitc (PA) dual-modal imaging-guided simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT), upon a single NIR laser irradiation.378