کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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67349 | 48478 | 2008 | 7 صفحه PDF | دانلود رایگان |
The atom economic hydroamination, the addition of an amine to an alkene, gained more and more importance as an “eco-friendly” alternative in amine synthesis. In this work the homogeneous catalytic 1,4-hydroamination of an unsaturated δ-lactone the 2-ethylidene-6-heptene-5-olide is investigated leading to a selective formation of an amino acid in a single step. The δ-lactone can be obtained by the telomerisation of the easily accessible 1,3-butadiene and the green house gas carbon dioxide. A new reactor concept is introduced which allows practical high-throughput catalyst screening with low costs. Variation of the metal precursors and the phosphorous ligands, optimisation of temperature and determinations of reaction rates leads to the catalyst system Al(OTf)3/DPEphos, which combines high activity (TOF = 846 h−1), no side products, low costs and low toxicity.
The homogeneous catalytic 1,4-hydroamination of the 2-ethylidene-6-heptene-5-olide (δ-lactone), obtained by the telomerisation of easily accessible 1,3-butadiene and the green house gas carbon dioxide, is described, yielding an amino acid in a single step. A new reactor concept is introduced which allows practical high-throughput catalyst screening with low costs.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 287, Issues 1–2, 15 May 2008, Pages 95–101