کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817025 | 1433882 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subcortical volumetric differences between clinical stages of young people with affective and psychotic disorders
ترجمه فارسی عنوان
اختلاف حجمی زیر فرعی بین مراحل بالینی جوانان با اختلالات عاطفی و روانی
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کلمات کلیدی
LSTCSOFASK10BPRSDSMMANCOVAHDRSSPSSBOLDbipolar disorder - اختلال دو قطبیSchizophrenia - اسکیزوفرنی یا شیزوفرنیDepression - افسردگیMajor depression - افسردگی شدیدMRI - امآرآی یا تصویرسازی تشدید مغناطیسیStatistical Package for the Social Sciences - بسته های آماری برای علوم اجتماعیMultivariate analysis of covariance - تجزیه و تحلیل چند متغیره کوواریانسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceNeuroimaging - تصویربرداری عصبیICD - دفیبریلاتورهای کاردیوورتر کاشتنیDiagnostic and Statistical Manual of Mental Disorders - راهنمای تشخیصی و آماری اختلالهای روانیPsychosis - روان پریشیInternational Classification of Diseases - طبقه بندی بین المللی بیماری هاgrey matter - ماده خاکستریEarly intervention - مداخله زودهنگامSocial and Occupational Functioning Assessment Scale - مقیاس ارزیابی عملکرد اجتماعی و اجتماعیHamilton Depression Rating Scale - مقیاس رتبه بندی افسردگی همیلتونBrief Psychiatric Rating Scale - مقیاس رتبه بندی روانپزشکی کوتاهblood-oxygen-level dependent - وابسته به سطح اکسیژن خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The aim of this study was to investigate differences in subcortical and hippocampal volumes between healthy controls, young people at an early stage of affective and psychotic disorders and those in more advanced stages, to identify markers associated with functional outcomes and illness severity. Young people presenting to youth mental health services with admixtures of depressive, manic and psychotic symptoms (n = 141), and healthy counterparts (n = 49), aged 18-25 were recruited. Participants underwent magnetic resonance imaging, clinical assessments and were rated as to their current clinical stage. Eighty-four patients were classified at the attenuated syndrome stage (Stage 1b) and 57 were classified as having discrete and persistent disorders (Stage 2+). Automated segmentation was performed using NeuroQuant® to determine volumes of subcortical and hippocampus structures which were compared between groups and correlated with clinical and functional outcomes. Compared to healthy controls, Stage 2+ patients showed significantly reduced right amygdala volumes. Whereas Stage 1b patients showed significantly reduced left caudate volumes compared to healthy controls. Smaller left caudate volume correlated with greater psychological distress and impaired functioning. This study shows a clinical application for an automated program to identify and track subcortical changes evident in young people with emerging psychopathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 271, 30 January 2018, Pages 8-16
Journal: Psychiatry Research: Neuroimaging - Volume 271, 30 January 2018, Pages 8-16
نویسندگان
Peta S. Eggins, Sean N. Hatton, Daniel F. Hermens, Ian B. Hickie, Jim Lagopoulos,