کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6868959 681490 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple comparisons of treatments with skewed ordinal responses
ترجمه فارسی عنوان
مقایسه چندگانه درمان با پاسخ های ردیف شده
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نظریه محاسباتی و ریاضیات
چکیده انگلیسی
In clinical studies, treatment responses are frequently measured with an ordinal scale. To compare the efficacy of these treatments, one could employ either the proportional odds model or the latent normal model. However, these two models are inadequate for comparing treatments with highly skewed ordinal responses, due to the possibility of yielding an inflated type I error rate. To overcome this problem, the latent Weibull model has been suggested for investigating the efficacy difference between two treatments. For more general applications, this model is extended to include clinical trials with more than two treatments. Two testing procedures are derived: one for multiple comparisons with a control and the other for pairwise treatment comparisons. The testing procedures are also demonstrated with two clinical examples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Statistics & Data Analysis - Volume 104, December 2016, Pages 223-232
نویسندگان
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