Formulation development and statistical optimization of ibuprofen-loaded polymethacrylate microspheres using response surface methodology

- Microspheres were prepared by emulsion solvent evaporation method.
- Statistical optimization was done by response surface methodology.
- Optimized formulation showed satisfactory yield and drug entrapment efficiency.
- Particles were of spherical shape, smooth surface and good flowability.
- Optimized formulation ensured sustained release (>12 h) of ibuprofen.