کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7281128 | 1473920 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokine-induced sleep: Neurons respond to TNF with production of chemokines and increased expression of Homer1a in vitro
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کلمات کلیدی
Egr2short interfering RNAsTNFNPTX2IL-CD40LPtgs2NREMTNFR1SBSsiRNA - siRNARheumatoid arthritis - آرتریتروماتوئیدDepression - افسردگیNeuroinflammation - التهاب عصبیinterleukin- - اینترلوکینInflammatory bowel disease - بیماریهای التهابی رودهNon-rapid eye movement sleep - حرکت سریع چشم بدون خوابSickness behavior - رفتار بدtumor necrosis factor - فاکتور نکروز تومورprimary somatosensory cortex - قشر اسموتیسنسوری اولیهCD40 ligand - لیگاند CD40Sleep deprivation - محرومیت از خوابMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)Early growth response 2 - پاسخ رشد اولیه 2prostaglandin-endoperoxide synthase 2 - پروستاگلاندین اندپورکسید سنتاز 2tumor necrosis factor receptor 1 - گیرنده فاکتور نکروز تومور 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Interactions of neurons with microglia may play a dominant role in sleep regulation. TNF may exert its somnogeneic effects by promoting attraction of microglia and their processes to the vicinity of dendrites and synapses. We found TNF to stimulate neurons (i) to produce CCL2, CCL7 and CXCL10, chemokines acting on mononuclear phagocytes and (ii) to stimulate the expression of the macrophage colony stimulating factor (M-CSF/Csf1), which leads to elongation of microglia processes. TNF may also act on neurons by affecting the expression of genes essential in sleep-wake behavior. The neuronal expression of Homer1a mRNA, increases during spontaneous and enforced periods of wakefulness. Mice with a deletion of Homer1a show a reduced wakefulness with increased non-rapid eye movement (NREM) sleep during the dark period. Recently the TNF-dependent increase of NREM sleep in the dark period of mice with CD40-induced immune activation was found to be associated with decreased expression of Homer1a. In the present study we investigated the effects of TNF and IL-1β on gene expression in cultures of the neuronal cell line HT22 and cortical neurons. TNF slightly increased the expression of Homer1a and IL-1β profoundly enhanced the expression of Early growth response 2 (Egr2). The data presented here indicate that the decreased expression of Homer1a, which was found in the dark period of mice with CD40-induced increase of NREM sleep is not due to inhibitory effects of TNF and IL-1β on the expression of Homer1a in neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 47, July 2015, Pages 186-192
Journal: Brain, Behavior, and Immunity - Volume 47, July 2015, Pages 186-192
نویسندگان
Maureen Karrer, Martin Alexander Lopez, Daniel Meier, Cyril Mikhail, Omolara O. Ogunshola, Andreas Felix Müller, Laura Strauss, Mehdi Tafti, Adriano Fontana,